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3-Deazaneplanocin A hydrochloride

CAS No. 120964-45-6

3-Deazaneplanocin A hydrochloride ( DZNep hydrochloride;NSC 617989 hydrochloride;3-Deazaneplanocin hydrochloride )

Catalog No. M10782 CAS No. 120964-45-6

A highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    3-Deazaneplanocin A hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM.
  • Description
    A highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2; more potent than 3-deazaaristeromycin; induces EZH2 protein depletion, leads to cell death in several cancers and tumors; anticancer or antiviral agent.
  • Synonyms
    DZNep hydrochloride;NSC 617989 hydrochloride;3-Deazaneplanocin hydrochloride
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    120964-45-6
  • Formula Weight
    298.73
  • Molecular Formula
    C12H15ClN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N.[H]Cl
  • Chemical Name
    3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tseng CK, et al. J Med Chem. 1989 Jul;32(7):1442-6.
2. Glazer RI, et al. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.
3. Fiskus W, et al. Blood. 2009 Sep 24;114(13):2733-43.
4. Puppe J, et al. Breast Cancer Res. 2009;11(4):R63.
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